A Natural Body Window to Study Human Pancreatic Islet Cell Function and Survival.
Year: 2013
Type: article
Abstract: , and we contrast such techniques with a recently established intravital approach using pancreatic islet transplantation into the anterior chamber of the eye. We also provide a summary of recent structure-function studies in the human pancreas to reveal distinctive features of human islets compared with mouse islets. We finally touch on a recently renewed discussion of the validity of animal models in studying human health and disease, and we highlight the potential utility of "humanized" animal models in studying different aspects of human islet biology and improving our understanding of diabetes.
Source: PubMed
Authors: M H Abdulreda, A Caicedo, P-O Berggren
Institutions: University of Miami, Karolinska Institutet
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication, Role of macrophages in pancreatic islet graft rejection, The Role of Innervation for Hormone Secretion in Human Islets, Glutamate Signaling in Human Islets of Langerhans, The Role of Innervation for Hormone Secretion in Human Islets, Noninvasive two-photon imaging of pancreatic islet graft rejection in the eye
OpenAlex ID: W2958985403