Work

5-Arylaminouracil Derivatives as Potential Dual-Action Agents

Year: 2015

Type: article

Abstract: Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5-40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (MT-4 cells) and ex vivo (human tonsillar tissue).

Source: Acta Naturae

DOI: 10.32607/20758251-2015-7-3-113-115

Authors: E. S. Matyugina, M. S. Novikov, D. A. Babkov, V. T. Valuev-Elliston, C. Vanpouille, S. Zicari, A. Corona, E. Tramontano, L. B. Margolis, A. L. Khandazhinskaya, S. N. Kochetkov

Institutions: Engelhardt Institute of Molecular Biology, Volgograd State Medical University, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Cagliari

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2959336226

FWCI:

Cites: 6

Cited by: 5

Related to: 10