Year: 2019
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To determine the time required for a preclinical Alzheimer disease population to decline in a meaningful way, use estimates of decline to update previous clinical trial design assumptions, and identify factors that modify β-amyloid (Aβ)-related decline. METHODS: In 1,120 cognitively unimpaired individuals from 3 international cohorts, we estimated the relationship between Aβ status and longitudinal changes across multiple cognitive domains and assessed interactions between Aβ and baseline factors. Power analyses were performed to explore sample size as a function of treatment effect. RESULTS: Cognitively unimpaired Aβ+ participants approach mild cognitive impairment (MCI) levels of performance 6 years after baseline, on average. Achieving 80% power in a simulated 4-year treatment trial, assuming a 25% treatment effect, required 2,000 participants/group. Multiple factors interacted with Aβ to predict cognitive decline; however, these findings were all cohort-specific. Despite design differences across the cohorts, with large sample sizes and sufficient follow-up time, the Aβ+ groups declined consistently on cognitive composite measures. CONCLUSIONS: A preclinical AD population declines to the cognitive performance of an early MCI population in 6 years. Slowing this rate of decline by 40%-50% delays clinically relevant impairment by 3 years-a potentially meaningful treatment effect. However, assuming a 40%-50% drug effect highlights the difficulties in preclinical AD trial design, as a more commonly assumed treatment effect of 25% results in a required sample size of 2,000/group. Designers of preclinical AD treatment trials need to prepare for larger and longer trials than are currently being considered. Interactions with Aβ status were inconsistent and not readily generalizable.
Source: Neurology
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: U.S. Department of Defense, Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Eli Lilly and Company, Pfizer, Sanofi, Biogen, University of Pennsylvania, Northwestern University, Synarc, Harvard University, Danone, Johns Hopkins University, Science and Industry Endowment Fund, Dementia Collaborative Research Centres, Australia, National Brain Research Centre, H. Lundbeck A/S, Yulgilbar Foundation, National Institutes of Health, Genentech, University of California, Los Angeles, University of California, San Diego, Avid Radiopharmaceuticals, Medical Research Council, National Health and Medical Research Council, National Institute on Aging, National Institute of Mental Health
OpenAlex ID: W2959949899