Work

Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development

Year: 2019

Type: review

Abstract: Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.

Source: Annual Review of Cell and Developmental Biology

DOI: 10.1146/annurev-cellbio-100818-125403

Authors: Prachi Bagadia, Xiao Huang, Tian-Tian Liu, Kenneth M. Murphy

Institutions: Washington University in St. Louis, Howard Hughes Medical Institute

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

Funders: Howard Hughes Medical Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: Function of Wdfy4 in cross-presentation and immunity, Understanding the Mechanisms of DC Licensing in CD8 T Cell Priming, Molecular Basis of cDC1 Development