Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+T Cells in Nonhuman Primates
Year: 2019
Type: article
Abstract: Due to the near monomorphic nature of MHC-E in the human population and inability of many pathogens to inhibit MHC-E-mediated peptide presentation, MHC-E-restricted T cells have become an attractive vaccine target. However, little is known concerning how these cells are induced. Understanding the underlying mechanisms that induce these T cells would provide a powerful new vaccine strategy to an array of neoplasms and viral and bacterial pathogens. Recent studies have indicated a link between TAP inhibition and induction of MHC-E-restricted T cells. The significance of our research is in demonstrating that TAP inhibition alone does not prime MHC-E-restricted T cell generation and suggests that other, currently unknown mechanisms regulate their induction.
Source: Journal of Virology
DOI: 10.1128/jvi.00592-19
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: A universal MHC-E-restricted T cell vaccine for HIV, Understanding Unconventional CD8+ T cell Responses in Protection from HIV, Non-canonical epitope presentation and antigen processing by MHC-E, Support for National Primate Research Center, SPF 4 Rhesus Macaque Breeding Colony for AIDS Research
OpenAlex ID: W2961204061