Work

T Cell Dysfunction in Cancer Immunity and Immunotherapy

Year: 2019

Type: article

Abstract: In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good results in cancer patients. Here, we review the hallmarks of T cell dysfunction in cancer. Also, we discuss the relationship between T cell dysfunction and cancer immunotherapy.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2019.01719

Authors: Anliang Xia, Yan Zhang, Jiang Xu, Tailang Yin, Xiao-Jie Lu

Institutions: Jiangsu Province Hospital, Wuhan University, Renmin Hospital of Wuhan University, Second People’s Hospital of Huai’an

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950