Work

Inhibition of Wnt/β-catenin by anthelmintic drug niclosamide effectively targets growth, survival, and angiogenesis of retinoblastoma.

Year: 2017

Type: article

Abstract: efficacy of carboplatin and inhibited Wnt/β-catenin signaling in a retinoblastoma xenograft mouse model. Our data suggest that niclosamide is a promising candidate for the treatment armamentarium for retinoblastoma. Our work also highlights that targeting Wnt/β-catenin is a potential therapeutic strategy in retinoblastoma.

Source: PubMed Central

Authors: Zhi Li, Qin Li, Genguo Wang, Yi Huang, Xiaochun Mao, Yanfang Zhang, Xueyan Wang

Institutions: Hubei University of Arts and Science, Xiangyang Central Hospital

Language: English

Topic: Ocular Oncology and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2962747849

FWCI: 2.698

Cites: 43

Cited by: 22

Related to: 10