TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages
Year: 2019
Type: article
Abstract: Significance Activators of interferons have received a great deal of interest in recent decades, both due to the central role they play in host defense against a range of pathogens, as well as the now well-recognized importance of dysregulated interferon activation/signaling in the pathogenesis of a number of highly prevalent and hard-to-treat diseases, such as systemic lupus erythematosus (SLE). Therefore, novel regulators of interferon activation are being sought as they may provide better targets to treat these diseases. We report the discovery of TMEM203 as an SLE-associated gene and a regulator of ligand-dependent activation of interferon production via STING. Thus, our work could form the basis of a novel therapeutic strategy for the treatment of interferonopathies, including SLE.
Authors: Yang Li, Sharmy J. James, David H. Wyllie, Claire Wynne, Agnes Czibula, Ahmed Bukhari, Katherine Pye, Seri Musfirah Bte Mustafah, Roberta Fajka-Boja, Eniko Szabo, Adrienn Angyal, Zoltan Hegedus, Laszlo Kovacs, Adrian V. S. Hill, Caroline A. Jefferies, Heather L. Wilson, Zhang Yongliang, Endre Kiss-Toth
Institutions: University of Sheffield, National University of Singapore, Life Sciences Institute, University of Oxford, Jenner Institute, Technological University Dublin, HUN-REN Szegedi Biológiai Kutatóközpont, Institute of Genetics, Hungarian Academy of Sciences, University of Pecs, University of Szeged, Cedars-Sinai Medical Center, The University of Osaka
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,635
OpenAlex ID: W2963039496