Contributions of HIV, hepatitis C virus, and traditional vascular risk factors to peripheral artery disease in women
Year: 2019
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: HIV and hepatitis C virus (HCV) have been associated with cardiovascular disease (CVD), but it is unclear whether HIV and HCV are also associated with peripheral artery disease (PAD). We examined the association of HIV, HCV, and traditional CVD risk factors with PAD in the Women's Interagency HIV Study, a multicenter US cohort. METHODS: In this cross-sectional study, ankle-brachial index was estimated using Doppler ultrasound and manual sphygmomanometer in 1899 participants aged more than 40 years with HIV/HCV coinfection, HCV or HIV monoinfection, or neither infection. Multivariable logistic regression was used to estimate the odds of PAD (ankle-brachial index ≤0.9) after controlling for demographic, behavioral, and CVD risk factors. RESULTS: Over two-thirds were African-American, median age was 50 years, and PAD prevalence was 7.7% with little difference by infection status. After multivariable adjustment, neither HIV nor HCV infection was associated with greater odds of PAD. Factors associated with PAD included older age [adjusted odds ratio (aOR): 2.01 for age 61-70 vs. 40-50 years; 95% confidence interval (CI): 1.04, 3.87], Black race (aOR: 2.30; 95% CI: 1.15, 4.63), smoking (aOR: 1.27 per 10-pack-year increment; 95% CI: 1.09, 1.48), and higher SBP (aOR: 1.14 per 10 mmHg; 95% CI: 1.01, 1.28). CONCLUSION: The high PAD prevalence in this nationally representative cohort of women with or at risk for HIV is on par with general population studies in individuals a decade older than our study's median age. HIV and HCV infection are not associated with greater PAD risk relative to uninfected women with similar risk factors. Modifiable traditional CVD risk factors may be important early intervention targets in women with and at risk for HIV.
Source: AIDS
Institutions: University of North Carolina at Chapel Hill, San Francisco VA Medical Center, Johns Hopkins University, University of Miami, Emory University, University of Alabama, University of California, San Francisco, Georgetown University, University of Alabama at Birmingham, Cook County Health and Hospitals System, Columbia University, Georgetown University Medical Center, Albert Einstein College of Medicine
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Veterans Affairs, Gilead Sciences, American College of Gastroenterology, Northern California Institute for Research and Education, Georgia Clinical and Translational Science Alliance, National Institutes of Health, Center for AIDS Research, University of Washington, University of California, San Francisco, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, National Institute of Dental and Craniofacial Research, Office of Research on Women's Health, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1255407591, G2034299771, G208418196, HIV, HCV, and gender effects on Liver, Bone, and Vascular Health, Acute Effects of Cannabis on Cognition and Mobility in Older HIV-Infected and Uninfected Women", Emory WIHS CRS - Longitudinal Cohort, G2800002786, G2839755957, Visceral Adiposity, HIV, and HCV: Biologic Mediators of Hepatic Steatosis, G3181090803, The Connie Wofsy Women's HIV Study, Brooklyn Women's Interagency HIV Study (WIHS) V, Miami Womens Interagency HIV Study WIHS, G4371267688, WIHS Data Management and Analysis Center (WDMAC), G4541905479, Southern California Women's Interagency HIV Study Consortium, Chicago WIHS Consortium V (CWC), Washington Women's Interagency HIV/AIDS Study, Clinical and Translational Science Institute, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, G6212232794, G6300780520, G6990385686, University of North Carolina Womens Interagency HIV Study UNC WIHS, G767062161, G775892330, G7807729167, Women's Interagency HIV Study (WIHS-V), G8846374971, UAB-MISS WIHS Cohort, G9000059561, G9000078127, G9000080293, G9000122276, UCSF Liver Center, SF Bay Area MACS/WIHS Combined Cohort Study, UNC MACS/WIHS Combined Cohort Study Clinical Research Site, Center for AIDS Research at Emory University, The University of North Carolina Center for AIDS Research, UCSF-Bay Area Center for AIDS Research, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS)
OpenAlex ID: W2963051748