Regulation of low-density lipoprotein receptor expression by AKT signaling
Year: 2019
Type: dissertation
Abstract: The presence of high blood cholesterol levels, hypercholesterolemia, is a significant contributing factor to the development of coronary heart disease, a condition that is the leading cause of death for both women and men in industrialized countries. Low-density lipoprotein receptor (LDLR) plays a crucial role in the uptake of cholesterol from the blood, and up-regulation of LDLR is therefore a useful strategy for the treatment of hypercholesterolemia. We have investigated the AKT signal pathway, and how inhibition of AKT increases LDLR protein levels and LDL cholesterol uptake by two different mechanisms, by both increasing transcription of the LDLR gene and decreasing the LDLR mRNA decay rate.
Author: Katrine Bjune
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2963119028