Work

Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility

Year: 2019

Type: article

Study design: Case Report

Abstract: We report patient-to-patient transmission of Enterobacter hormaechei isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the Ω-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibactam therapy, whereas the second patient had not received the agent and still became colonized with the KPC-40-producing strain.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00955-19

Authors: L. Silvia Munoz-Price, Allison E. Reeme, Blake W. Buchan, Roberta T. Mettus, Mustapha M. Mustapha, Daria Van Tyne, Ryan K. Shields, Yohei Doi

Institutions: Medical College of Wisconsin, Froedtert Hospital, University of Pittsburgh, Fujita Health University

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Eye Institute, National Institute of Allergy and Infectious Diseases

Awards: Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasis, Bacterial Evasion of Innate Defenses at the Ocular Surface, Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP), Colistin resistance in extensively drug-resistant Gram-negative pathogens, Characterization and suppression of resistance to new CRE agents

OpenAlex ID: W2963176622

FWCI: 1.295

Cites: 13

Cited by: 23

Related to: 10