Work

Nonlinear Interferometric Vibrational Imaging

Year: 2004

Type: article

Abstract: Coherent anti-Stokes Raman scattering (CARS) processes are "coherent," but the phase of the anti-Stokes radiation is lost by most incoherent spectroscopic CARS measurements. We propose a Raman microscopy imaging method called nonlinear interferometric vibrational imaging, which measures Raman spectra by obtaining the temporal anti-Stokes signal through nonlinear interferometry. With a more complete knowledge of the anti-Stokes signal, we show through simulations that a high-resolution Raman spectrum can be obtained of a molecule in a single pulse using broad band radiation. This could be useful for identifying the three-dimensional spatial distribution of molecular species in tissue.

Source: Physical Review Letters

DOI: 10.1103/physrevlett.92.123905

Authors: Daniel L. Marks, Stephen A. Boppart

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Aeronautics and Space Administration, National Institutes of Health, University of Illinois at Urbana-Champaign, National Cancer Institute

OpenAlex ID: W2963206047

FWCI: 7.864

Cites: 23

Cited by: 129

Related to: 10