Work

Dissipative Particle Dynamics Simulations of Self-Assemblies of Liposomes for Drug Delivery Applications

Year: 2019

Type: book-chapter

Abstract: Liposomes are essential components in the development of functional materials for drug delivery; this is mainly due to its ability to self-associate spontaneously and form bilayer vesicles. In these potential applications, knowing the size of self-assembled liposomes is essential for optimal performance; however, this process still has many unanswered questions. Conventional experimental techniques to study self-assemblies of liposome nanoparticles still have a great challenge. Computational simulations emerge as an alternative to understand the role of thermodynamic properties responsible for the self-assembly, particularly when they are unreachable experimentally because of limited time and length resolutions. In this chapter, we present the advantages and disadvantages of dissipative particle dynamic method to explore the functioning of liposome self-assembly in the transport of drugs.

Source: IntechOpen eBooks

DOI: 10.5772/intechopen.85812

Authors: Ketzasmin Armando Terrón-Mejía, Inocencio Higuera-Ciapara, Evelin Martínez-Benavidez, Javier Hernández, Roberto López-Rendón

Institutions: Universidad Autónoma del Estado de México, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, Universidad Veracruzana

Language: English

Topic: Lipid Membrane Structure and Behavior

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Consejo Nacional de Ciencia y Tecnología, Universidad Autónoma del Estado de México

Award: G3454007709