Work

Feedback between E2F1 and CIP2A regulated by human papillomavirus E7 in cervical cancer: implications for prognosis.

Year: 2017

Type: article

Abstract: . Moreover, CIP2A and E2F1 expression was greatly elevated in human cervical cancer tissue. CIP2A expression was tightly associated with tumor size, depth of invasion and lymph node metastasis in 184 cases of cervical cancer. Kaplan-Meier and Cox proportional-hazards regression analyses revealed poor overall and disease-free survival of patients with CIP2A-E2F1 co-expression, and high CIP2A-E2F1 co-expression was an independent risk factor for overall survival of patients. Therefore, CIP2A-E2F1 expression might be a valuable indicator to predict outcome and guide personal treatment in cervical cancer.

Source: Europe PMC (PubMed Central)

Authors: Xiao Wang, Peng Gao, Meng Wang, Jing Liu, Jiaxiang Lin, Shule Zhang, Yiwei Zhao, Jingwen Zhang, Wei Pan, Zeyu Sun, Feifei Sun, Weiming Zhao, Chenghao Guo, Qingwei Wang

Institutions: Shandong University, Qilu Hospital of Shandong University, Jining First People's Hospital

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2963550915

FWCI: 1.511

Cites: 34

Cited by: 13

Related to: 10