Work

Continuous evolution of base editors with expanded target compatibility and improved activity

Year: 2019

Type: article

Source: Nature Biotechnology

DOI: 10.1038/s41587-019-0193-0

Authors: B W. Thuronyi, Luke W. Koblan, Jonathan M. Levy, Wei-Hsi Yeh, Christine Zheng, Gregory A. Newby, Christopher Wilson, Mantu Bhaumik, Olga Shubina-Oleinik, Jeffrey R. Holt, David R. Liu

Institutions: Broad Institute, Harvard University, Williams College, Boston Children's Hospital, Howard Hughes Medical Institute

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Defense, Howard Hughes Medical Institute, U.S. Department of Health and Human Services, National Institutes of Health, Defense Advanced Research Projects Agency, National Human Genome Research Institute, National Institute on Deafness and Other Communication Disorders, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering

Awards: G125295407, G1864136703, Harvard Chemical Biology Graduate Program, G3405342043, Expanding the Scope of Base Editing, G4630203202, THE PURPOSE OF THIS COOPERATIVE AGREEMENT IS TO FUND RESEARCH IN SUPPORT TO BTO IN THE AMOUNT OF 750,000 ON CONTRACT HR0011-17-2-0049., G6855349143, Continuous Evolution of Proteins with Novel Therapeutic Potential, G7699325053, Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics, TMC gene function in sensory hair cells, Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease

OpenAlex ID: W2963629338

FWCI: 11

Cites: 65

Cited by: 337

Related to: 10