MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses
Year: 2019
Type: article
Abstract: The process of mitochondrial fission-fusion has been implicated in diverse neuronal roles including neuronal survival, axon degeneration, and axon regeneration. However, whether increased fission or fusion is beneficial for neuronal health and/or axonal growth is not entirely clear, and is likely situational and cell type-dependent. In searching for mitochondrial fission-fusion regulating proteins for improving axonal growth within the visual system, we uncover that mitochondrial fission process 1,18 kDa (MTP18/MTFP1), a pro-fission protein within the CNS, is critical to maintaining mitochondrial size and volume under normal and injury conditions, in retinal ganglion cells (RGCs). We demonstrate that MTP18's expression is regulated by transcription factors involved in axonal growth, Kruppel-like factor (KLF) transcription factors-7 and -9, and that knockdown of MTP18 promotes axon growth. This investigation exposes MTP18's previously unexplored role in regulating mitochondrial fission, implicates MTP18 as a downstream component of axon regenerative signaling, and ultimately lays the groundwork for investigations on the therapeutic efficacy of MTP18 expression suppression during CNS axon degenerative events.
Source: Scientific Reports
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,790
Awards: G1411628592, Molecular Discovery for Optic Nerve Regeneration, G2100497953, Role of growth and differentiation factors in retinal ganglion cell development, G2827949003, The role of mitochondrial fission/fusion in CNS axon regeneration, G3150481158, G3433871507, G426147107, G4570518681, G4701869429, G4896855234, Miami Center for Vision Research, G721603795, G7741333592, G800051844, G8160389401, G8515245412, Transmission Electron Microscope, G8869866276, G9000020482, G9000240259, G9000266758, G9000342939, Stanford Vision Research Core
OpenAlex ID: W2963824045