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Fluid assessment in dialysis patients by point-of-care magnetic relaxometry

Year: 2019
Type: article
Study design: Observational Study
Abstract: measurements of the lower leg of patients with ESRD immediately before and after dialysis were compared to those of euvolemic healthy controls using both a 0.28-T bedside single-voxel NMR sensor and a 1.5-T clinical MRI scanner. In the MRI data, we found that the first sign of fluid overload was an expanded muscle extracellular fluid (ECF) space, a finding undetectable at this stage using physical exam. A decrease in muscle ECF upon fluid removal was similarly detectable with both the bedside sensor and MRI. Bioimpedance measurements performed comparably to the bedside NMR sensor but were generally worse than MRI. These findings suggest that bedside NMR may be a useful method to identify fluid overload early in patients with ESRD and potentially other hypervolemic patient populations.
DOI: 10.1126/scitranslmed.aau1749
Authors: Lina A. Colucci, Kristin M. Corapi, Matthew Li, Xavier Vela Parada, Andrew S. Allegretti, Herbert Y. Lin, Dennis A. Ausiello, Matthew S. Rosen, Michael J. Cima
Institutions: Harvard–MIT Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Massachusetts General Hospital, Harvard University, Athinoula A. Martinos Center for Biomedical Imaging
Language: English
Open Access status: green
Funders: Massachusetts Institute of Technology, National Institutes of Health, U.S. Air Force, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences
OpenAlex ID: W2963909354
FWCI: 1.946
Cites: 61
Cited by: 27
Related to: 10