Work

Amphotericin B Induction with Voriconazole Consolidation as Salvage Therapy for FKS -Associated Echinocandin Resistance in Candida glabrata Septic Arthritis and Osteomyelitis

Year: 2019

Type: article

Abstract: We report the case of a 61-year-old female with Crohn’s disease dependent on total parenteral nutrition who developed a central venous catheter bloodstream infection and septic arthritis, complicated further by osteomyelitis and persistent Candida glabrata fungemia. Fluconazole treatment led to persistent infection, and micafungin therapy failed with development of FKS -associated resistance. Infection responded after initiation of amphotericin B plus voriconazole.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00512-19

Authors: William F. Wright, Nika Bejou, Ryan K. Shields, Kieren Marr, Todd P. McCarty, Peter G. Pappas

Institutions: University of Pittsburgh Medical Center, Johns Hopkins University, Johns Hopkins Medicine, University of Alabama at Birmingham

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases