Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer
Year: 2019
Type: article
Study design: Observational Study
Abstract: Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to bacterial flagellin C (FliC), a measure potentially related to this impairment, with CRC and the CRC-specific interaction with antibodies to SGG proteins. Antibodies to FliC and SGG pilus proteins Gallo2178 and Gallo2179 were measured in two independent studies, a combined study from Nijmegen and Detroit (93 CRC cases, 74 controls) and a replication data set including 576 cases and 576 controls from the Spanish multicenter multicase-control study (MCC-Spain). Logistic regression was applied to assess whether antibodies to FliC were associated with CRC and modified the association of antibodies to SGG proteins with CRC. Antibodies to FliC were associated with those to SGG Gallo2178 among CRC cases, resulting in an interaction in the association of antibodies to Gallo2178 with CRC (p = 0.007). This association was only present among individuals with high antibody responses to FliC (OR: 2.42, 95% CI: 1.45-4.06). In conclusion, our findings suggest that colorectal tumorigenesis could be accompanied by an impaired integrity of the epithelium that could result in associated increased antibody responses to bacterial proteins.
Source: Scientific Reports
Authors: Julia Butt, Nerea Fernández de Larrea, Harold Tjalsma, Rian Roelofs, Ikuko Kato, Vicente Martín, Beatriz Pérez-Gómez, Victor Moreno, Trinidad Dierssen-Sotos, Jesús Castilla, Guillermo Fernández-Tardón, Pilar Amiano, Dolores Salas, Juan Alguacil, José Juan Jiménez-Moleón, José María Huerta, Silvia de Sanjosé, Rosa del Campo, Manolis Kogevinas, Marina Pollán, Michael Pawlita, Tim Waterboer, Annemarie Boleij, Nuria Aragonés
Institutions: German Cancer Research Center, Heidelberg University, Instituto de Salud Carlos III, Centro Nacional de Epidemiología, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Wayne State University, Universidad de León, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat de Barcelona, Universidad de Cantabria, Instituto de Investigación Marqués de Valdecilla, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Universidad de Oviedo, Biogipuzkoa Health Research Institute, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Universidad de Huelva, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Instituto Murciano de Investigación Biosanitaria, Program for Appropriate Technology in Health, Red Espanola de Investigacion en Patologia Infecciosa, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Universitat Pompeu Fabra, Municipal Institute for Medical Research, Barcelona Institute for Global Health, Hospital del Mar Research Institute
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,790
Funders: U.S. Department of Health and Human Services, Generalitat de Catalunya, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Junta de Castilla y León, Xarxa de Bancs de Tumors de Catalunya, National Institutes of Health, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III, National Cancer Institute
Awards: G1203044189, G1274129560, G1677669578, G178315305, G1900157527, G2117726266, G248046784, G2553834064, G2620658983, Estudio de las interacciones microbioma-anfitrión para la prevención del cáncer colorrectal (Colonbiome), G2739777946, G3559709381, G3771020718, G3807906117, Identificación de marcadores de susceptibilidad genética útiles para el diseño de estrategias personalizadas de cribado, G4502495630, G4540457744, G4561499809, G4623508005, G5394670091, G556022927, G5578384164, G6260981759, G6737142931, G7352723158, G7868651054, Luminal Lipid Exposure, Genetics and Colon Cancer Risk, G848664173, G8759146715, G8931017233
OpenAlex ID: W2964175347