Year: 2019
Type: article
Abstract: Oxidative stress and nitrosative stress are defined as a disruption of redox signaling and control.Homeostatic concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a crucial role as secondary messengers in many intracellular signaling pathways; however, excess ROS can lead to cell and tissue injuries [1,2].The major sources of vascular ROS are NAD(P)H oxidase, mitochondrial-derived superoxide, and uncoupled nitric oxide synthase [3].Increasing studies have shown a close relationship between angiogenesis and oxidative stress in both physiological and pathological conditions, and oxidative damage plays a major role in vascular dysfunction, leading to endothelial dysfunction and inflammation.As the field of redox biology employs new techniques to quantitatively measure the amount of ROS/RNS generated, innovative strategies are being developed to therapeutically target redox imbalance in vascular disease.This issue consists of 7 papers highlighting different therapeutic approaches targeting redox damage in cardiomyopathy, hypertension, skin disease, and diabetic retinopathy.L. Chang et al. studied the role of ZYZ-803 molecule in acute myocardial infarction (AMI).Their work showed that ZYZ-803 protects heart tissues against acute myocardial ischemia via the targeting of ERS-related necroptosis by downregulating the RIP3-CaMKII pathway.The molecule further regulates H 2 S and NO homeostasis via releasing both H 2 S and NO.This opens up avenues to test the molecule as a candidate in AMI therapeutics.In the review by X. Yang et al., the authors discuss about therapeutic application of traditional Chinese medicines for treating coronary heart diseases (CHD).Increased oxidative
DOI: 10.1155/2019/3764252
Authors: J. Banerjee, J. Ghose, M. Sinha, S. Sen
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
OpenAlex ID: W2964204972