The genetic diversity of multiple sclerosis risk among Hispanic and African American populations living in the United States
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Substantial progress has been made toward unraveling the genetic architecture of multiple sclerosis (MS) within populations of European ancestry, but few genetic studies have focused on Hispanic and African American populations within the United States. OBJECTIVE: = 200) within these populations. METHODS: Genotype data were available on 2652 Hispanics (1298 with MS, 1354 controls) and 2435 African Americans (1298 with MS, 1137 controls). We conducted single variant, pathway, and cumulative genetic risk score analyses. RESULTS: We found less replication than statistical power suggested, particularly among African Americans. This could be due to limited correlation between the tested and causal variants within the sample or alternatively could indicate allelic and locus heterogeneity. Differences were observed between pathways enriched among the replicating versus all 200 variants. Although these differences should be examined in larger samples, a potential role exists for gene-environment or gene-gene interactions which alter phenotype differentially across racial and ethnic groups. Cumulative genetic risk scores were associated with MS within each study sample but showed limited diagnostic capability. CONCLUSION: These findings provide a framework for fine-mapping efforts in multi-ethnic populations of MS.
Source: Multiple Sclerosis Journal
Institutions: University of Miami, Dr. John T. Macdonald Foundation, University of Southern California, Central University of the Caribbean, Kyushu University, University of California, San Francisco, Universitat Autònoma de Barcelona, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Centre d'Esclerosi Múltiple de Catalunya, Brigham and Women's Hospital, Harvard University, Johns Hopkins University, Johns Hopkins Medicine, Columbia University Irving Medical Center
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Individualized Risk Stratification Using the Genomic Contribution, G1153146029, Genetic and Phenotypic Analysis of Multiple Sclerosis in Hispanics, Parent-of-origin effect in multiple sclerosis susceptibility, G483337511, Southern California Clinical and Translational Science Institute, Gene linkage study of multiple sclerosis sibling pairs, G8644413907, Southern California Clinical and Translational Science Institute, Imaging Neurodegeneration in Multiple Sclerosis
OpenAlex ID: W2964549800