Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system
Year: 2019
Type: preprint
Abstract: The bacterial flagellum is a complex, self-assembling, nanomachine that confers motility on the cell. Despite great variation across species, all flagella are ultimately constructed from a helical propellor attached to a motor embedded in the inner membrane. The motor consists of a series of stator units surrounding a central rotor made up of two ring complexes, the MS-ring and the C-ring. Despite many studies, high resolution structural information is still completely lacking for the MS-ring of the rotor, and proposed mismatches in stoichiometry between the two rings have long provided a source of confusion for the field. We here present structures of the Salmonella MS-ring, revealing an unprecedented level of inter- and intra-chain symmetry variation that provides a structural explanation for the ability of the MS-ring to function as a complex and elegant interface between the two main functions of the flagellum, protein secretion and rotation.
DOI: 10.1101/718072
Institution: University of Oxford
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: Defining the cytoplasmic architecture that control bacterial type three secretion, Molecular mechanisms in complement regulation and evasion., G1694809557, G1885233162, G2927492771, Establishing a feeder EM facility for South Parks Road Oxford, G40969420, G5942286159, How does the Pericentriolar Matrix function in Centrosome Biology?
OpenAlex ID: W2964596460