Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis
Year: 2019
Type: article
Study design: Observational Study
Abstract: Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatment serum from five groups to inform the association of sFLC with familial and sporadic CLL: (1) familial CLL (n = 154), (2) sporadic CLL (n = 302), (3) familial MBL (n = 87), (4) unaffected first-degree relatives from CLL/MBL families (n = 263), and (5) reference population (n = 15,396). The percent of individuals having elevated monoclonal and polyclonal sFLCs was compared using age-stratified and age- and sex-adjusted logistic regression models. In age groups >50 years, monoclonal sFLC elevations were increased in sporadic and familial CLL cases compared to the reference population (p's < 0.05). However, there were no statistically significant differences in sFLC monoclonal or polyclonal elevations between familial and sporadic CLL cases (p's > 0.05). Unaffected relatives and MBL cases from CLL/MBL families, ages >60 years, showed elevated monoclonal sFLC, compared to the reference population (p's < 0.05). This is the first study to demonstrate monoclonal sFLC elevations in CLL cases compared to controls. Monoclonal sFLC levels may provide additional risk information in relatives of CLL probands.
Source: Blood Cancer Journal
Authors: Alyssa I. Clay-Gilmour, Abdul R. Rishi, Lynn R. Goldin, Alexandra J. Greenberg-Worisek, Sara J. Achenbach, Kari G. Rabe, Matthew J. Maurer, Neil E. Kay, Tait D. Shanafelt, Timothy G. Call, J. Brice Weinberg, Nicola J. Camp, James R. Cerhan, Jose Leis, Aaron Norman, David L. Murray, S. Vincent Rajkumar, Neil E. Caporaso, Ola Landgren, Mary L. McMaster, Susan L. Slager, Celine M. Vachon
Institutions: Mayo Clinic, Mercy Hospital, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Stanford Medicine, Stanford University, Duke University, Duke Medical Center, University of Utah, Huntsman Cancer Institute, Mayo Clinic in Arizona, Mayo Clinic Hospital, Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,380
Awards: G1106065612, G1174881085, G1923666891, G2020395215, G2053184807, G2660289629, G2779496123, Genetic Epidemiology of Chronic Lymphocytic Leukemia, G3170985386, G3695342494, Mayo Cancer Genetic Epidemiology Training Program, GENETIC EPIDEMIOLOGY OF CHRONIC LYMPHOCYTIC LEUKEMIA, G6622425196, G6848433621, Molecular Epidemiology of NHL and CLL, Lymphoma Specialized Program of Research Excellence (SPORE) in Human Cancer, G9000035104, G9000077327, G9000085525, G9000088907, G9000128122, G9000185500, G9000193977, G9000209416, G9000236397, G9000345581, Cancer Center Support Grant, Cancer Center Support Grant (CCSG)
OpenAlex ID: W2964753393