Work

Medial prefrontal cortex in neurological diseases

Year: 2019

Type: article

Abstract: The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer's disease, Parkinson's disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00006.2019

Authors: Pan Xu, Ai Chen, Yipeng Li, Xuezhi Xing, Hui Lu

Institutions: George Washington University, Affiliated Hospital of Southwest Medical University

Language: English

Topic: Neural and Behavioral Psychology Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke