Work

Strategy for improved therapeutic efficiency of curcumin in the treatment of gastric cancer

Year: 2019

Type: article

Abstract: Gastric cancer is a common oncological disease. Although enormous efforts have been expended, possible therapeutic modalities are still limited. For this reason, new therapeutic approaches and agents are highly requested and intensively developed. One strategy is the application of natural agents, such as curcumin, with proven anticancer effects and low toxicity for patients. Therefore, this review discusses the potential application of curcumin in the therapy of gastric cancer and its potential incorporation in therapeutic regimens. Because one of the largest impediments for widespread curcumin application is its limited bioavailability (caused mainly by its very low water solubility), studied strategies (drug delivery systems and curcumin derivatization) aimed to solve this obstacle are discussed in more detail.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2019.109278

Authors: Milan Jakubek, Zdeněk Kejík, Robert Kaplánek, Róbert Hromádka, Viera Šandriková, David Sýkora, Veronika Antonyová, Marian Urban, Petr Dytrych, Ivan Mikula, Pavel Martásek, Vladimír Král

Institutions: Charles University, General University Hospital in Prague, University of Chemistry and Technology, Prague, Food Research Institute Prague

Language: English

Topic: Curcumin's Biomedical Applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000

Funders: Univerzita Karlova v Praze, Technology Agency of the Czech Republic, Ministerstvo Školství, Mládeže a Tělovýchovy, Grantová Agentura České Republiky, Ministerstvo Průmyslu a Obchodu, Ministerstvo Zemědělství

Awards: G1059663884, G1074099231, G12500569, G1342419356, G1476925882, G1568528057, G1578938374, G1708673118, G1730565977, G1799217667, G1919522010, G1935710221, G2390358516, G249715745, G2526206997, G2784031255, Prague University Analytical Centre II and III - NPU 2015-2020, G3194548175, Improved growth of human skin cells on biomimetic nanofibrous matrices for active wound healing, G3761626526, G4131035492, Center for Development of Original Drugs, G4443488180, G4927920098, G5226939889, G5267022763, G5641063287, Adjuvant therapy, G6191335359, G6393581779, G6693508342, G6761430300, Spray nebulization drying - new way to preservation of nutraceutics activities., G7144489796, G7338263410, G7444195239, G7485778940, G777586394, G817933029, G8343850630, G8375299074, BIOCEV: from Fundamental to Applied Research, G8905092842, G99050831

OpenAlex ID: W2964992986

FWCI: 3.103

Cites: 127

Cited by: 65

Related to: 10