Work

Computational approaches for characterizing the tumor immune microenvironment

Year: 2019

Type: article

Abstract: Recent advances in high-throughput molecular profiling technologies and multiplexed imaging platforms have revolutionized our ability to characterize the tumor immune microenvironment. As a result, studies of tumor-associated immune cells increasingly involve complex data sets that require sophisticated methods of computational analysis. In this review, we present an overview of key assays and related bioinformatics tools for analyzing the tumor-associated immune system in bulk tissues and at the single-cell level. In parallel, we describe how data science strategies and novel technologies have advanced tumor immunology and opened the door for new opportunities to exploit host immunity to improve cancer clinical outcomes.

Source: Immunology

DOI: 10.1111/imm.13101

Authors: Candace C. Liu, Chloé B. Steen, Aaron M. Newman

Institutions: Stanford Medicine, Stanford University, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute