Work

Performance of a Defect-Mapping Microperimetry Approach for Characterizing Progressive Changes in Deep Scotomas

Year: 2019

Type: article

Abstract: Purpose: To examine whether a microperimetry testing strategy based on quantifying the spatial extent of functional abnormalities (termed “defect-mapping” strategy) could improve the detection of progressive changes in deep scotomas compared to the conventional thresholding strategy. Methods: A total of 30 healthy participants underwent two microperimetry examinations, each using the defect-mapping and thresholding strategies at the first visit to examine the test–retest variability of each method. Testing was performed using an isotropic stimulus pattern centered on the optic nerve head (ONH), which acted as a model of a deep scotoma. These tests were repeated at a second visit, except using a smaller stimulus pattern and thereby increasing the proportion of test locations falling within the ONH (to simulate the progressive enlargement of a deep scotoma). The extent of change detected between visits relative to measurement variability was compared between the two strategies. Results: Relative to their effective dynamic ranges, the test–retest variability of the defect-mapping strategy (1.8%) was significantly lower compared to the thresholding strategy (3.3%; P < 0.001). The defect-mapping strategy also captured a significantly greater extent of change between visits relative to variability (−4.70 t−1) compared to the thresholding strategy (2.74 t−1; P < 0.001). Conclusions: A defect-mapping microperimetry testing strategy shows promise for capturing the progressive enlargement of deep scotomas more effectively than the conventional thresholding strategy. Translational Relevance: Microperimetry testing with the defect-mapping strategy could provide a more accurate clinical trial outcome measure for capturing progressive changes in deep scotomas in eyes with atrophic retinal diseases, warranting further investigations.

Source: Translational Vision Science & Technology

DOI: 10.1167/tvst.8.4.16

Authors: Zhichao Wu, Roberta Cimetta, Emily Caruso, Robyn H. Guymer

Institutions: The University of Melbourne, The Royal Victorian Eye & Ear Hospital, Centre for Eye Research Australia

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850