Work

The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397

Year: 2019

Type: article

Abstract: VL-2397 (previously termed ASP2397) is an antifungal, aluminum-chelating cyclic hexapeptide with a structure analogous to that of ferrichrome-type siderophores, whereby replacement of aluminum by iron was shown to decrease the antifungal activity of this compound. Here, we found that inactivation of an importer for ferrichrome-type siderophores, termed Sit1, renders Aspergillus fumigatus resistant to VL-2397.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00807-19

Authors: Anna-Maria Dietl, Matthias Misslinger, Mario M. Aguiar, Vasyl Ivashov, David Teis, Joachim Pfister, Clemens Decristoforo, Martin Hermann, Sean M. Sullivan, Larry R. Smith, Hubertus Haas

Institutions: Innsbruck Medical University, Universität Innsbruck, Vical (United States)

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Austrian Science Fund

Awards: Novel molecular mechanisms of iron sensing and homeostasis in filamentous fungi, Mechanism of nutrient dependent plasma membrane remodeling, G6095061343

OpenAlex ID: W2965362820

FWCI: 4.984

Cites: 45

Cited by: 54

Related to: 10