Lipokines and Thermogenesis
Year: 2019
Type: review
Abstract: Adaptive thermogenesis is a catabolic process that consumes energy-storing molecules and expends that energy as heat in response to environmental changes. This process occurs primarily in brown and beige adipose tissue. Thermogenesis is regulated by many factors, including lipid derived paracrine and endocrine hormones called lipokines. Recently, technologic advances for identifying new lipid biomarkers of thermogenic activity have shed light on a diverse set of lipokines that act through different pathways to regulate energy expenditure. In this review, we highlight a few examples of lipokines that regulate thermogenesis. The biosynthesis, regulation, and effects of the thermogenic lipokines in several families are reviewed, including oloeylethanolamine, endocannabinoids, prostaglandin E2, and 12,13-diHOME. These thermogenic lipokines present potential therapeutic targets to combat states of excess energy storage, such as obesity and related metabolic disorders.
Source: Endocrinology
Authors: Matthew D Lynes, Sean D Kodani, Yu-Hua Tseng
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Regulation of human brown and beige adipocyte differentiation and function, Fibroblast Growth Factor and Energy Metabolism, The Lipidomics of Adipose Tissue Thermogenesis, G3907630707, Telomerase as a Marker of Brown and White Adipose Tissue Stem Cells, Training Grant in Diabetes and Metabolism, Diabetes Research Center
OpenAlex ID: W2965965447