Work

Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161

Year: 2019

Type: article

Abstract: VT-1161 and VT-1598 are promising investigational tetrazole antifungals that have shown in vitro and in vivo activity against Candida and other fungi. Candida glabrata is a problematic opportunistic pathogen that is associated with high mortality in invasive infection, as well as both intrinsic and rapidly acquired antifungal resistance.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01304-19

Authors: Andrew T. Nishimoto, Sarah G. Whaley, Nathan P. Wiederhold, Qing Zhang, Christopher M. Yates, William J. Hoekstra, Robert J. Schotzinger, Edward P. Garvey, P. David Rogers

Institutions: University of Tennessee Health Science Center, The University of Texas at San Antonio Health Science Center, Viamet Pharmaceuticals (United States)

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Award: Upc2A: A Central Regulator and "Achilles' Heel" of Fluconazole Resistance in Candida glabrata

OpenAlex ID: W2966463840

FWCI: 2.682

Cites: 40

Cited by: 31

Related to: 10