Work

Depletion-of-susceptibles Bias in Analyses of Intra-season Waning of Influenza Vaccine Effectiveness

Year: 2019

Type: article

Abstract: Bias arises in studies of waning vaccine effectiveness when higher-risk individuals are depleted from the at-risk population at different rates between study groups. We examined how this bias arises and how to avoid it. A reanalysis of data from California confirmed a finding of intra-season waning of influenza vaccine effectiveness.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciz706

Authors: G Thomas Ray, Ned Lewis, Nicola P Klein, Matthew F Daley, Marc Lipsitch, Bruce Fireman

Institutions: Kaiser Permanente, Kaiser Permanente Northern California, University of Colorado Anschutz, Harvard University

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases