Work

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27 Kip1 signaling axis

Year: 2019

Type: article

Abstract: signaling axis, but growth is inhibited in the confining slow-relaxing hydrogels. Thus, in confining microenvironments, cells sense when growth is sufficient for division to proceed through a growth-responsive signaling axis mediated by SACs.

Source: Science Advances

DOI: 10.1126/sciadv.aaw6171

Authors: Sungmin Nam, Vivek Kumar Gupta, Hong-pyo Lee, Joanna Y. Lee, Katrina M. Wisdom, Sushama Varma, Eliott Marie Flaum, Ciara Davis, Robert B. West, Ovijit Chaudhuri

Institutions: Stanford University, Stanford Medicine, University of Michigan

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

Funders: National Science Foundation, National Cancer Institute

Awards: Investigating the Mechanics of Cell Division with A Side-View Atomic Force Microscope, G8326600702, Stanford Cancer Institute

OpenAlex ID: W2966828582

FWCI: 9.5

Cites: 60

Cited by: 193

Related to: 10