Simultaneous 13N-Ammonia and gadolinium first-pass myocardial perfusion with quantitative hybrid PET-MR imaging: a phantom and clinical feasibility study
Year: 2019
Type: article
Abstract: Positron emission tomography (PET) is the non-invasive reference standard for myocardial blood flow (MBF) quantification. Hybrid PET-MR allows simultaneous PET and cardiac magnetic resonance (CMR) acquisition under identical experimental and physiological conditions. This study aimed to determine feasibility of simultaneous 13 N-Ammonia PET and dynamic contrast-enhanced CMR MBF quantification in phantoms and healthy volunteers. Images were acquired using a 3T hybrid PET-MR scanner. Phantom study: MBF was simulated at different physiological perfusion rates and a protocol for simultaneous PET-MR perfusion imaging was developed. Volunteer study: five healthy volunteers underwent adenosine stress. 13 N-Ammonia and gadolinium were administered simultaneously. PET list mode data was reconstructed using ordered subset expectation maximisation. CMR MBF was quantified using Fermi function-constrained deconvolution of arterial input function and myocardial signal. PET MBF was obtained using a one-tissue compartment model and image-derived input function. Phantom study: PET and CMR MBF measurements demonstrated high repeatability with intraclass coefficients 0.98 and 0.99, respectively. There was high correlation between PET and CMR MBF ( r = 0.98, p < 0.001) and good agreement (bias − 0.85 mL/g/min; 95% limits of agreement 0.29 to − 1.98). Volunteer study: Mean global stress MBF for CMR and PET were 2.58 ± 0.11 and 2.60 ± 0.47 mL/g/min respectively. On a per territory basis, there was moderate correlation ( r = 0.63, p = 0.03) and agreement (bias − 0.34 mL/g/min; 95% limits of agreement 0.49 to − 1.18). Simultaneous MBF quantification using hybrid PET-MR imaging is feasible with high test repeatability and good to moderate agreement between PET and CMR. Future studies in coronary artery disease patients may allow cross-validation of techniques.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,627
Funders: Wellcome Trust, National Institute for Health and Care Research, British Heart Foundation, King's College London, European Commission, Rosetrees Trust, Medical Research Council, Engineering and Physical Sciences Research Council, Centre For Medical Engineering, King’s College London, European Metrology Programme for Innovation and Research
Awards: G1054121244, G1211483440, G1247657515, G1271318647, King's College London Medical Engineering Centre of Research Excellence, Novel Cardiac MRI methods for the diagnosis of coronary artery disease compared to PET imaging and Invasive Coronary Angiography: A cohort study and health economic evaluation for patient benefit., G1526879960, G1855327598, Novel Cardiac MRI techniques for the diagnosis of coronary artery disease compared to PET imaging and Invasive Coronary Angiography., G2417159676, G3171527865, The BHF Chair of Cardiovascular Imaging, G434337789, G4806164323, Using PET Imaging to improve survival and reduce side-effects of treatment for patients with cancer, G5296857752, G5877788390, G5893523844, G5896571142, King's College London Medical Engineering Centre of Research Excellence, G8303168876, G8775246936, G938335843, G961285871
OpenAlex ID: W2967044726