Work

Impact of cerebral blood flow level on the fluctuations of resting-state BOLD fMRI in anesthetized rats

Year: 2018

Type: conference-paper

Abstract: The Blood Oxygen Level Dependent (BOLD) signal, used in resting-state functional Magnetic Resonance Imaging (fMRI), is tighly linked to Cerebral Blood Flow (CBF). This study evaluates the impact of the CBF on the low-frequencies BOLD fluctuations and four physiological parameters during resting state in 5 groups of rats (Wistar and Long-Evans) anesthetized with Isoflurane, Medetomidine, Etomidate and Urethane. It is shown that the CBF is not related to physiological parameters, and there exists a range of CBF values where the BOLD fluctations are sufficiently high for being used in any other analysis.

Source: HAL

Authors: Achard, Sophie, Becq, Guillaume,, Habet, Tarik, Collomb, Nora, Faucher, Margaux, Delon-Martin, Chantal, Coizet, Véronique, Barbier, Emmanuel,

Institutions: GIPSA-Lab, Grain Inspection, Packers and Stockyards Administration, Grenoble Institute of Neurosciences, Inserm

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2967184991

FWCI:

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