The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice
Year: 2019
Type: article
Abstract: female mice had normal fertility until mid-adulthood. We conclude that the H3K4me3 reader ZCWPW1 is indispensable for meiosis synapsis in males but is dispensable for females. Our results suggest that ZCWPW1 may represent a previously unknown, sex-dependent epigenetic regulator of germ cell meiosis in mammals.
Source: Science Advances
Institutions: Shandong University, Shandong Provincial Hospital, Hospital for Reproductive Medicine Affiliated to Shandong University, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Stem Cell and Reproductive Biology, Center for Excellence in Molecular Cell Science, State Key Laboratory of Molecular Biology, University of Hong Kong - Shenzhen Hospital, University of Hong Kong, China Agricultural University, Chinese University of Hong Kong, Shanghai Jiao Tong University, Renji Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,500
Award: G106319253
OpenAlex ID: W2967247947