Using Synthetic Lethality to Sensitize Pediatric Brain Cancer Cells to the DNA Damaging Effects of Radiation Therapy
Year: 2018
Type: article
Abstract: Brain tumors are the leading cause of cancer related deaths in children. As a treatment, radiotherapy is very effective, but it also comes with many severe side effects, such as radiation-induced adverse developmental and psychosocial effects.2 Cancer, because it is a mutagenic disease, is by definition a disease of DNA repair pathways. Here we utilize drugs to inhibit various DNA repair pathways with the purpose of sensitizing cancer cells to radiotherapy so that lower doses may be used. Hopefully this would improve the lifelong outcomes of patients that would otherwise not survive or would be left with lifelong neurocognitive problems.
Source: Lincoln (University of Nebraska)
Authors: Megan Ruckman, Rose Nelson, Forrest M. Kievit
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2967532967