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Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer

Year: 2019

Type: article

Abstract: Envelope glycoprotein (Env) spikes on the surface of human immunodeficiency virus (HIV-1) bind target cell receptors, triggering changes in the shape of Env. We studied a small molecule, MF275, that also induced shape changes in Env. The consequences of MF275 interaction with Env depended on the HIV-1 strain, with infection by some viruses inhibited and infection by other viruses enhanced. These studies reveal the strain-dependent diversity of HIV-1 Envs as they undergo shape changes in proceeding down the entry pathway. Appreciation of this diversity will assist attempts to develop broadly active inhibitors of HIV-1 entry.

Source: Journal of Virology

DOI: 10.1128/jvi.01197-19

Authors: Connie Zhao, Amy M. Princiotto, Hanh T. Nguyen, Shitao Zou, Meiqing Lily Zhao, Shijian Zhang, Alon Herschhorn, Mark Farrell, Karanbir Pahil, Bruno Melillo, Somisetti V. Sambasivarao, Cameron Abrams, Amos B. Smith, Navid Madani, Joseph Sodroski

Institutions: Dana-Farber Cancer Institute, University of Minnesota, Harvard University, University of Pennsylvania, Drexel University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: amfAR, The Foundation for AIDS Research, Ragon Institute of MGH, MIT and Harvard, National Natural Science Foundation of China, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Structure-Based Antagonism of HIV-1 Envelope Function in Cell Entry, G1219148038, G1723375129, G2659053460, G5724941342, G6873031519, Design of dendrimeric HIV-1 transmission inhibitors targeting gp120 Phe-43 cavity, G9000041998, Conformational Landscape of the HIV-1 Envelope Glycoproteins, G979994218

OpenAlex ID: W2967673177

FWCI:

Cites: 87

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Related to: 10