Work

Involvement of the low molecular weight G protein Rac1 in IL-1 signalling to NFkB activation

Year: 2001

Type: dissertation

Abstract: The involvement of the low molecular weight G protein Rac1 in IL-1 signal transduction has been suggested by studies that have demonstrated that a dominant negative mutant of Rac1 can inhibit IL-1-induced activation of both p38 and JNK mitogen activated protein kinase (MAPK) pathways. This prompted the investigation into the role of Rac1 in other IL-1-induced events in T lymphocytes, namely its ability to drive IL-2 expression, using the IL-1 receptor rich murine thymoma cell line EL4.N0B-1.

Source: Arrow@dit (Dublin Institute of Technology)

Author: Caroline A. Jefferies

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2967818686

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