Gas-generating nanoparticles for contrast-enhanced ultrasound imaging
Year: 2019
Type: article
Abstract: We present gas-generating solid nanoparticles as a new concept of an ultrasound contrast agent. The developed nanoparticles are sufficiently small (less than 100 nm in diameter) to escape vasculature and yet, upon external pulsed laser light activation, release nitrogen gas for enhanced contrast in ultrasound imaging. The gas-generating nanoconstructs combine the photocatalytic function of gold nanoparticles and photolysis of azide compounds. Using ultrasound imaging, we demonstrate the controlled, on-demand generation of nitrogen gas from nanoparticles due to the decomposition of azide groups triggered by pulsed laser irradiation. The resulting gas forms bubbles that cause backscattered ultrasound signals and, therefore, modulate the contrast in ultrasound imaging.
Source: Nanoscale
DOI: 10.1039/c9nr04471j
Authors: In-Cheol Sun, Stanislav Emelianov
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: Acoustic Imaging of Sentinel Node Matastasis using Plasmonic Nanosensors, Molecular photothermal therapy of cancer using targeted metal nanoparticles, G3172177039, Functional, cellular, and molecular imaging and therapy monitoring using ultrasou, Nebraska Center for Integrated Biomolecular Communication (CIBC)
OpenAlex ID: W2968170302