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Comparative Analgesic Properties of Bupivacaine, Etidocaine, and Lidocaine in Mice

Year: 1984

Type: article

Abstract: The analgesic properties of bupivacaine, etidocaine, and lidocaine were compared following intraperitoneal injection in mice. Two evaluations of analgesia were employed: the hot plate test and the stretch test. Doses of 75% of their corresponding CD50s produce analgesia greater than control and less than morphine sulfate 5 mg/kg. When differences in the pharmacokinetic properties of the agents are evaluated, the relative analgesic properties of the three local anesthetics appear nearly identical.

Source: Regional Anesthesia The Journal of Neural Blockade in Obstetrics Surgery & Pain Control

DOI: 10.1136/rapm-00115550-198409020-00009

Authors: Paul A. Moore, Robert G. Burney, Harry A. Dunlevy

Institutions: Harvard University, University of Massachusetts Chan Medical School

Language: English

Topic: Anesthesia and Pain Management

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2968350164

FWCI:

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