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Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

Year: 2019
Type: review
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine therapeutic failure. In this review, we present the current status and the recent advances in PDAC treatment together with the biological and immunological hallmarks of this cancer entity. On this basis, we discuss new concepts combining distinct treatment modalities in order to improve therapeutic efficacy and clinical outcome - with a specific focus on protocols involving radio(chemo)therapeutic approaches.
DOI: 10.1186/s13014-019-1345-6
Authors: Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr, Kirsten Lauber
Institutions: German Cancer Research Center, LMU Klinikum, Deutsches Konsortium für Translationale Krebsforschung, Ludwig-Maximilians-Universität München, Center for Integrated Protein Science Munich, TUM Klinikum, Technical University of Munich
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,490
Awards: G2863253698, G5964850865, G6022757005, G6736111635, G6853878338, G844791446
OpenAlex ID: W2968934833
FWCI: 5.533
Cites: 283
Cited by: 528
Related to: 10