A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division
Year: 2019
Type: article
Abstract: Significance The Arabidopsis R2R3-MYB transcription factor FOUR LIPS (FLP) is the first identified key transcription factor regulating stomatal development. By screening and analyzing a genetic suppressor of flp stomatal defects, we found that FSP1/RPA2a , which encodes a core subunit of Replication Protein A (RPA) complexes, acts downstream of B1-type Cyclin-Dependent Kinases (CDKB1s). This ensures that terminal division during stomatal development will produce a pair of kidney-shaped guard cells to compose a functional stomatal complex. We demonstrate that the CDK-mediated phosphorylation at the N terminus of RPA2a is essential for the RPA functions in cell cycle control and response to DNA damage. We provide direct evidence for the existence of an evolutionarily conserved, but plant-specific, RPA regulatory pathway in plants.
Institutions: Chinese Academy of Sciences, Center for Excellence in Molecular Plant Sciences, Institute of Botany, University of Chinese Academy of Sciences, Minzu University of China, Shanghai University, Rutgers, The State University of New Jersey, Ghent University, VIB-UGent Center for Plant Systems Biology, Ghent University Global Campus
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2969334035