Work

ATG2A transfers lipids between membranes in vitro

Year: 2019

Type: article

Abstract: ATG2 is a rod-shaped membrane-tethering protein suggested to mediate the endoplasmic reticulum (ER)-phagophore association and the expansion of the phagophore. We recently demonstrated that human ATG2A transfers lipids between membranes in vitro, which led us to propose a model that the phagophore expands upon the transfer of lipids from the ER by ATG2. Here, we summarize our findings and arising issues that need to be addressed to establish the mechanism of phagophore expansion.

Source: Autophagy

DOI: 10.1080/15548627.2019.1659622

Authors: Takanori Otomo, Shintaro Maeda

Institution: Scripps Research Institute

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Molecular mechanisms of autophagosome biogenesis