Omega-3 treatment in hypoxicischemic brain injury: An experimental study in newborn piglets
Year: 2019
Type: dissertation
Abstract: Neonatal encephalopathy, and hereunder hypoxia-ischemia, is a major cause of newborn and pediatric morbidity and mortality. Survivor phenotypes range from mild learning disability to severe neurodevelopmental delay. \nTherapeutic hypothermia is the only established treatment for hypoxic-ischemic encephalopathy, and it significantly reduces both mortality and morbidity in the moderately affected encephalopathic infants. But still large numbers of infants develop sequelae and adjuvant neuroprotective strategies are warranted. \nIn this thesis, Marianne U. Huun and colleagues have used a well-established newborn piglet model of hypoxia-ischemia to explore a novel neuroprotectant, the omega-3 fatty acid docosahexaenoic acid (DHA). In the model DHA was administered in combination with and without therapeutic hypothermia. Lipid peroxides as markers of oxidative stress were measured in urine, blood and brain tissue. H+MRS was applied on frozen brain tissue and neuropathology was analyzed to exploratory assess reductions in oxidative stress and neuroprotection.
Author: Marianne Ullestad Huun
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2969597066