Work

Methamphetamine Use and Cardiovascular Disease

Year: 2019

Type: article

Abstract: While the opioid epidemic has garnered significant attention, the use of methamphetamines is growing worldwide independent of wealth or region. Following overdose and accidents, the leading cause of death in methamphetamine users is cardiovascular disease, because of significant effects of methamphetamine on vasoconstriction, pulmonary hypertension, atherosclerotic plaque formation, cardiac arrhythmias, and cardiomyopathy. In this review, we examine the current literature on methamphetamine-induced changes in cardiovascular health, discuss the potential mechanisms regulating these varied effects, and highlight our deficiencies in understanding how to treat methamphetamine-associated cardiovascular dysfunction.

Source: Arteriosclerosis Thrombosis and Vascular Biology

DOI: 10.1161/atvbaha.119.312461

Authors: Christopher G. Kevil, Nicholas E. Goeders, Matthew D. Woolard, Md. Shenuarin Bhuiyan, Paari Dominic, Gopi K. Kolluru, Connie L. Arnold, James G. Traylor, A. Wayne Orr

Institutions: Louisiana State University in Shreveport, Louisiana State University Health Sciences Center Shreveport

Language: English

Topic: Substance Abuse Treatment and Outcomes

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: G1277892170, G1361688239, Sigma-1 receptor and cardioprotection, G1937633654, Nck adaptor proteins in atherogenic endothelial activation, Sigma-1 receptor and cardioprotection, G4825808388, Macrophage- associated lipin-1 lipid synthesis regulates foam cell inflammatory responses, Center for Redox Biology and Cardiovascular Disease, Louisiana Clinical and Translational Science Center

OpenAlex ID: W2969628213

FWCI: 17.19

Cites: 66

Cited by: 294

Related to: 10