Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated Vibrio cholerae
Year: 2019
Type: article
Abstract: An episode of cholera provides better protection against reinfection than oral cholera vaccines, and the reasons for this are still under study. To better understand this, we compared the immune responses of human cells exposed to live Vibrio cholerae with those of cells exposed to heat-killed V. cholerae (similar to the contents of oral cholera vaccines). We also compared the effects of active cholera toxin and the inactive cholera toxin B subunit (which is included in some cholera vaccines). One key immune signaling molecule, IL-23, was uniquely produced in response to the combination of live bacteria and active cholera holotoxin. Stimulation with V. cholerae that did not produce the active toxin or was killed did not produce an IL-23 response. The stimulation of IL-23 production by cholera toxin-producing V. cholerae may be important in conferring long-term immunity after cholera.
Source: mSphere
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,500
Awards: G1422189682, G2878635176, O-Specific Polysaccharide Responses and Cholera, The gut microbiome and susceptibility to Vibrio cholerae, Innate and early B cell responses to V. cholerae, G8084686412, Humoral and adaptive immune responses study in Vibrio cholerae infection, O-Specific Polysaccharide Responses and Cholera, International research training program in vaccine development and public health, Infectious Disease and Basic Microbiological Mechanisms
OpenAlex ID: W2969659361