Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival
Year: 2019
Type: article
Study design: Observational Study
Abstract: Background: Leukocyte telomere length has been associated with risk of subsequent pancreatic cancer. Few prospective studies have evaluated the association of prediagnostic leukocyte telomere length with pancreatic cancer survival. Methods: We prospectively examined the association of prediagnostic leukocyte telomere length with overall survival (OS) time among 423 participants diagnosed with pancreatic adenocarcinoma between 1984 and 2008 within the Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, and Women's Health Initiative. We measured prediagnostic leukocyte telomere length in banked blood samples using quantitative PCR. Cox proportional hazards models were used to estimate HRs for OS with adjustment for potential confounders. We also evaluated 10 SNPs at the telomerase reverse transcriptase locus. Results: Shorter prediagnostic leukocyte telomere length was associated with reduced OS among patients with pancreatic cancer (Ptrend = 0.04). The multivariable-adjusted HR for OS comparing the lowest with highest quintiles of leukocyte telomere length was 1.39 (95% confidence interval, 1.01–1.93), corresponding to a 3-month difference in median OS time. In an analysis excluding cases with blood collected within 2 years of cancer diagnosis, the association was moderately stronger (HR, 1.55; 95% confidence interval, 1.09–2.21; comparing the lowest with highest quintiles; Ptrend = 0.01). No prognostic association or effect modification for the prognostic association of prediagnostic leukocyte telomere length was noted in relation to the studied SNPs. Conclusions: Prediagnostic leukocyte telomere length was associated with pancreatic cancer survival. Impact: Prediagnostic leukocyte telomere length can be a prognostic biomarker in pancreatic cancer.
Authors: Tsuyoshi Hamada, Chen Yuan, Ying Bao, Mingfeng Zhang, Natalia Khalaf, Ana Babic, Vicente Morales-Oyarvide, Barbara B. Cochrane, J. Michael Gaziano, Edward L. Giovannucci, Peter Kraft, JoAnn E. Manson, Kimmie Ng, Jonathan A. Nowak, Thomas E. Rohan, Howard D. Sesso, Meir J. Stampfer, Laufey T. Amundadottir, Charles S. Fuchs, Immaculata De Vivo, Shuji Ogino, Brian M. Wolpin
Institutions: Harvard University, Dana-Farber Cancer Institute, Brigham and Women's Hospital, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, University of Washington, VA Boston Healthcare System, Albert Einstein College of Medicine, Yale Cancer Center, Yale University, Smilow Cancer Hospital, Broad Institute, Massachusetts Institute of Technology
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1160275816, G1851278524, G1907824982, G2214254730, Biochemical Markers in the nurses' Health Study Cohort, G3062349281, G3101773556, G3643850837, Dietary and Hormonal Determinants of Cancer in Women, G4522543292, G4582778782, G459566519, G4763206504, Physicians' Health Study II: Prevention Trial of Vitamins, G6388140822, TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'S, G6777873208, G7332203415, Cancer Epidemiology Cohort in Male Health Professionals, G8554986239, G8606882599, G9000000635, G9000019617, G9000043482, G9000050131, G9000090346, G9000099730, Leveraging Novel Randomized Clinical Trials of Vitamin D Supplementation in Patients with Colorectal Cancer: Impact on Survival and Anti-Tumor Immunity, Altered metabolism and machine learning for pancreatic cancer early detection
OpenAlex ID: W2969670569