Work

Does APC/CCDH1 control the human brain size?

Year: 2019

Type: editorial

Abstract: This editorial highlights a study by Rodriguez, Sanchez‐Moran et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors describe a microcephalic boy carrying the novel heterozygous de novo missense mutation c.560A> G; p.Asp187Gly in Cdh1/Fzr1 encoding the APC/C E3‐ubiquitin ligase cofactor CDH1. A functional characterization of mutant APC/CCDH1 confirms an aberrant division of neural progenitor cells, a condition known to determine the mouse brain cortex size. These data suggest that APC/CCDH1 may contribute to the regulation of the human brain size. image

Source: Journal of Neurochemistry

DOI: 10.1111/jnc.14835

Authors: Maike F. Dohrn, Juan P. Bolaños

Institutions: RWTH Aachen University, Universidad de Salamanca, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Biología Funcional y Genómica

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,000