Work

Immunotherapy of Liver Diseases

Year: 2019

Type: article

Abstract: As an immunological organ, the liver played critical roles against invading pathogens.Many immune cells such as Kupffer cells, natural killer (NK) cells, and NKT cells were located in the liver under normal physiological condition.Under pathological condition, such as acute or chronic liver injury, more immune cells migrated into the liver.These cells may act as friends to clear damaged hepatocytes, promote liver repair, improve the resolution of liver fibrosis, and eliminate liver cancer cells.They may also play bad roles in the liver, such as further damaging hepatocytes, promoting hepatic stellate cell activation and live fibrosis, and facilitating tumor growth.So, how to understand the detailed regulation mechanisms in liver immune cells and how to target immune cells in the liver to improve the therapy of liver diseases are a challenging problem in the liver study field.In this special issue, we have invited a few Research Articles and Reviews that address such issues.In the paper titled "Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure," the authors studied the correlation of serum immunoglobulins including IgG, IgA, and IgM and interleukin-27 (IL-27) in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF).They compared HBV-ACLF patients with chronic hepatitis B (CHB) patients as well as normal control.They found that serum immunoglobulins were preferentially elevated in HBV-ACLF patients.In addition, serum IgG levels were positively correlated with IL-27.This study may be helpful for predicting prognosis in HBV-ACLF patients.

Source: Journal of Immunology Research

DOI: 10.1155/2019/9343505

Authors: Dechun Feng, YinYing Lu, Xiaoni Kong, Feng Li