Work

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

Year: 2019

Type: article

Source: Molecular Cell

DOI: 10.1016/j.molcel.2019.07.023

Authors: Su Myung Jung, Chien-Min Hung, Samuel R. Hildebrand, Joan Sanchez-Gurmaches, Barbara Martinez-Pastor, Jivani M. Gengatharan, Martina Wallace, Dimpi Mukhopadhyay, Camila Martinez Calejman, Amelia K. Luciano, Wen-Yu Hsiao, Yuefeng Tang, Huawei Li, Danette L. Daniels, Raul Mostoslavsky, Christian M. Metallo, David A. Guertin

Institutions: University of Massachusetts Chan Medical School, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Harvard University, Massachusetts General Hospital, University of California San Diego, Promega (United States)

Language: English

Topic: Adipose Tissue and Metabolism

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Foundation for the National Institutes of Health, American Diabetes Association, American Cancer Society, American Heart Association, Leukemia and Lymphoma Society, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G4038707337, Mechanistic Target of Rapamycin Pathways in Metabolism and Energy Expenditure, Spatial organization of the mTOR Complex 2 regulates lipid metabolism, Acetyl-CoA metabolism and nutrient sensing in adipocytes, Exploiting Metabloic Defects in Tumors with Mutant IDH1 and IDH2, Preventing cardiovascular disease by targeting its greatest risk factor'obesity, Developmental and molecular mechanisms of obesity., Elucidating the AKT-dependent and AKT-independent mechanisms of metabolic control by mTORC2

OpenAlex ID: W2969897457

FWCI: 7.554

Cites: 79

Cited by: 88

Related to: 10